Role of Genetic Ancestry in Oropharyngeal Squamous-Cell Carcinoma: A Cross-Sectional Study in Brazil

Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The different ethnic backgrounds could be related to susceptibility Human Papillomavirus (HPV). aim of our study was assess the whole genetic ancestry in status OPSCC patients. Methods: We conducted a cross-sectional on patients with admitted Barretos Cancer Hospital, Brazil from 2014 2019. Of these, DNA extraction performed 40 and assessed using specific panel 46 informative markers. Results: observed predominance European (63%), followed by African (18%), Amerindian (9%) Asian (8%) both HPV-positive HPV-negative group. did not find any statistically significant differences between groups relation (p = 0.499), 0.448), 0.275) or 0.836) ancestry. Conclusions: found ancestry, groups. In study, we